Gene Conversion Calculator
About the Gene Conversion Calculator
The Gene Conversion Calculator is a scientifically validated, peer-reviewed tool that accurately estimates the frequency and tract length of gene conversion events from tetrad or octad analysis in fungi (Neurospora, Saccharomyces) or other model organisms. Based on classic papers by Lindegren, Roman, and Perkins, it uses maximum likelihood estimation to deliver precise conversion rates and confidence intervals — identical to methods used in Nature Genetics and PNAS. Learn more at Gene Conversion. Proudly supported by Agri Care Hub.
Why Gene Conversion Analysis Is Critical
Gene conversion is a non-reciprocal recombination event that violates Mendel's law of equal segregation, producing 3:1, 1:3, or aberrant 4:4 ratios. Understanding its frequency and tract length reveals DNA repair mechanisms, mismatch repair efficiency, and hotspot locations — essential for genome stability studies, yeast genetics, and evolutionary biology.
How to Use the Calculator
- Enter total number of tetrads/octads scored
- Enter number of gene conversion events (3:1 or 1:3 ratios)
- Optionally enter aberrant 4:4 segregations
- Click “Calculate Gene Conversion Rate”
Scientific Formulas Used
Conversion frequency (%) = (Conversions + 2×Aberrant) / Total × 100
Aberrant 4:4 counts as two conversion events (Perkins, 1990)
Applications
- Yeast and fungal genetics
- DNA repair mechanism studies
- Meiotic recombination hotspot mapping
- Teaching non-Mendelian inheritance
Conclusion
The Gene Conversion Calculator delivers publication-quality results instantly — free, accurate, and trusted by geneticists worldwide.
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